Universidade De Santiago De Compostela

Consiglio Nazionale Delle Ricerche

Fin-Ceramica Faenza S.p.a.

José Rivas Rey

Anna Tampieri

Manuel Arturo Lopez Quintela

Daniele Pressato

Maurilio Marcacci

Monica Sandri

Elena Landi

Manuel Banobre López

María Carmen Blanco Varela

The present invention relates to hydroxyapatite doped with Feions and Feions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.

Intrinsically magnetic hydroxyapatite

The invention relates to the use of stable atomic quantum clusters (AQC) with antimicrobial activity. The stable AQCs include at least 500 metal atoms (Mn, n&#x3c;500), the metals being selected from among Au, Ag, Co, Cu, Pt, Fe, Cr, Pd, Ni, Rh, Pb or bi- or multi-metallic combinations thereof. Said AQCs are used as antimicrobial agents, antifungal agents and biocides at concentrations of the order of between 1 nM and 100 nM or more in relation to atoms of the corresponding metal. The antimicrobial activity is specific to both the type of metal and size of cluster used.

Use of atomic quantum cluster (AQC) as antimicrobial agents and biocides

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Ames, Spain

José Rivas Rey