Laboratorios Salvat, S.a.

José Hidalgo Rodriguez

Juan Lorenzo Catena Ruiz

Isabel Masip Masip

Carmen Lagunas Arnal

Carolina Salcedo Roca

María Del Carmen Serra Comas

Carmen Serra Comas

Anna Fernández Serrat

Dolors Balsa López

Andrés Fernández García

Maria Del Carmen Serra Comas

The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo[2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders.

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Compounds of general formula I, and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents &#x2014;(CH)&#x2014;N(COR)-A-J-T or &#x2014;(CH)&#x2014;N(R)&#x2014;B-J-T; and s. R3, R4, A, B, J and T have the meanings disclosed in the description. These compounds are PPAR&#x3b3; modulators and, therefore, are useful for the treatment or prevention of a condition or a disease mediated by these receptors. 

Tyrosine derivatives as PPAR-&#x3b3;-modulators

Growing community of inventors

Esplugues de Lilobregat, Spain

José Hidalgo Rodriguez