Proyecto De Biomedicina Cima, S.l.

José Antonio Páramo Fernández

Josune Orbe Lopategui

Julen Oyarzabal Santamarina

Rosario Serrano Vargas

José Antonio Rodriguez Garcia

Jóse Antonio Rodríguez García

José Antonio RODRÍGUEZ GARCÍA

José Antonio Rodríguez García

It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wherein A and B form a spirocyclic ring system wherein the spiro atom connecting A and B is a carbon atom and wherein A is a known 3- to 8-membered carbocyclic or heterocyclic monocyclic ring or a known 6- to 18-membered carbocyclic or heterocyclic polycyclic ring system; B is a known 4- to 7-membered carbocyclic or heterocyclic monocyclic ring; C is phenyl or a known 5- to 6-membered heteroaromatic ring; and R-Rare as defined herein. It also relates to a process for their preparation, as well as to the intermediates used in this process; to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular as antifibrinolytic and antihemorragic agents. 

Antifibrinolytic compounds

The present invention concerns the use of a neutralizing antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for hemorrhages and hemorrhagic complications of various etiologies.

Methods for anti-fibrinolytic treatment using MMP-10 neutralizing antibody

Growing community of inventors

Pamplona, Spain

José Antonio Páramo Fernández