Alternative Gene Expression, S.l.

Instituto Nacional De Investigacion Y Tecnologia Agraria Y Alimentaria

Instituto Nacional De Technologia Agropecuaria (inta)

Instituto Nacional De Tecnologia Agropecuaria

José Angel Martínez Escribano

Javier López Vidal

Andrés Wigdorovitz

Thomas Surrey

Aurelien Olichon

Lorena Laura Garaicoeachea

Gisela Ariana Marcoppido

Gladys Viviana Parreño

Silvia Gómez Sebastián

Félix Gil Dones

Agustin Ostachuk

Mariano Pèrez Filguera

Javier Dominguez

Carmen Núnez Serrano

Maria Josè Dus Santos

Ismael Sánchez Ramos

Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunization method, and treatment method for rotavirus infections, wherein said domain may be any of the amino acid sequences shown in SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3, and wherein said domains bind to protein VP6 of Group A rotavirus.

Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunisation method, composition, and treatment methods for rotavirus infections

Fusion protein with directioning of vaccinal antigens toward antigen-presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognizes the &#x3b2; chain of the class-II DR antigen present on the surface of antigen-presenting cells; and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins.

Fusion protein that directs vaccine antigens to antigen-presenting cells, and applications thereof

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Madrid, Spain

José Angel Martínez Escribano