Institut National De La Sante Et De La Recherche Medicale

Cis Bio International

Josette Michelot

Jean-Claude Madelmont

Denise Godeneche

Marie-France Moreau

Daniel Parry

Annie J Veyre

Pierre Lebarre

Gaston Meyniel

##STR1## The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z--CONH--, Z--O--, Z--S(O)--.sub.n1 group, n.sub.1 being equal to 0,1,2 or 3, a Z--SO.sub.2 --NH-- Z--NHCO-- group, Z being a bond, a --CH.sub.2 -- or --CH(C.sub.6 H.sub.5)-- group, n is an integer between 2 and 4, and R.sub.1 and R.sub.2 each denote a hydrogen atom, a C.sub.1 to C.sub.6 alkyl group or a C.sub.6 to C.sub.12 aryl or aralkyl group, these compounds possibly being labelled by radioisotopes chosen from .sup.123 I, .sup.123 I, .sup.123 I, .sup.75 Br, .sup.77 Br, .sup.18 F, or .sup.11 C or by stable isotopes chosen from .sup.13 C and .sup.19 F, as well as their addition salts with pharmaceutically acceptable acids. The invention also concerns the use of these compounds to manufacture an agent for diagnosing and/or treating malignant melanomas.

Agents for diagnosing and treating melanomas, aromatic halogenated

Growing community of inventors

Le Cendre, France

Josette Michelot