Janssen Pharmaceutica Nv

Janssen Pharmaceutica

Josephus L Van Gelder

Alfons H Raeymaekers

Henry Joseph Breslin

Michael Joseph Kukla

Paul A Janssen

Gustaaf Maria Boeckx

Willy Joannes Van Laerhoven

Leopold Frans Roevens

Lodewijk L Van Hemeldonck

Marc Gaston Venet

Eddy J Freyne

The compounds are of the class of tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing antiretroviral, especially anti-HIV-1, activity. An illustrative compound is (+)-S-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4 ,5,1-jk][1,4]benzodiazepine-2(1H)-thione. These compounds are represented by the formula: ##STR1## The application also discloses compositions containing these compounds as active ingredients and methods of treating subjects suffering from retroviral infections by administering said compounds.

Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones

Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds. The compounds have the basic structure shown in Formula (I): ##STR1##

Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones

(1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.

6-(1H-azol-1-ylmethyl)-1-(pyrimidinyloxy)-1H benzotriazoles

Novel 5-[4-(diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives having antiallergic and antihistaminic properties.

5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives

Compounds of the class of imidazo[1,2-a]-imidazoles, imidazo[1,2-a]pyrimidines and pyrimido-[1,2-a]pyrimidines useful as central nervous system (CNS) antidepressants; and certain novel precursors therefor.

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Kasterlee, Belgium

Josephus L Van Gelder