Mayo Foundation for Medical Education and Research

Euroimmun Medizinische Labordiagnostika Ag

Josephe A Honorat

Vanda A Lennon

Sean J Pittock

Andrew McKeon

Lars Komorowski

Yvonne Denno

Ramona Miske

Thomas J Kryzer

Madeleine Scharf

Christiane Radzimski

Stefanie Hahn

Mandy Unger

A method for diagnosing a disease can include detecting, in a sample from a patient, an autoantibody binding to Septin-7. A polypeptide comprising Septin-7 or a variant thereof can be used for the diagnosis of a disease. Preferably, the polypeptide is used to detect an autoantibody binding to Septin-7 in a sample. A kit is useful for the diagnosis of a disease. The kit may include a polypeptide that includes Septin-7 or a variant thereof or a medical device that includes a polypeptide that includes Septin-7 or a variant thereof and an autoantibody to Septin-7.

Autoantibodies to Septin-7 and diagnosis of neurological disease

Methods and materials herein are useful for assessing and/or treating autoimmune ataxias associated with septin-specific autoantibodies (e.g., septin-5-specific autoantibodies). For example, septin-5 polypeptides are provided as well as methods for using septin-5 polypeptides to detect septin-5-specific autoantibodies and/or to treat a mammal having an autoimmune ataxia.

Assessing and treating autoimmune ataxia

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Rochester, MN, United States of America

Josephe A Honorat