Janssen Pharmaceutica Nv

Josepha Eduarda Leysen

Georges H Van Daele

Anne Simone Lesage

Didier Robert De Chaffoy De Courcelles

Marc Joris De Brabander

This invention relates to the use of an .alpha.,.alpha.'-iminobis(methylene)bis[2-chromanmethanol] derivative for the manufacture of a medicament for the therapeutic or prophylactic treatment of humans suffering from or prone to degenerative diseases and conditions of the vascular and nervous system which are associated with oxidative stress.

Use of nebivolol as an anti-atherogenic

Use of fused benzothiazoles as neuroprotectants

Use of Nebivolol as an anti-atherogenic

Piperidinyl substituted benzamides of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is halo; R.sup.3 is hydrogen or halo; R.sup.4 and R.sup.5 each independently are hydrogen, C.sub.1-4 alkyl or haloC.sub.1-4 alkyl; and the group NR.sup.4 R.sup.5 may also be azido, Alk is C.sub.2-4 alkanediyl; pharmaceutical compositions containing said compounds of formula (I) as active ingredient; use of said compounds as a medicine; process of preparing said compounds; compounds of formula (I) containing a radioactive isotope; process of marking 5HT.sub.2 -receptor sites; and process for imaging an organ are disclosed.

4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides

4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamides

4-amino-N-(4-methyl-4-piperidinyl)-2-methoxybenzamides for treating

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Oud-Turnhout, Belgium

Josepha Eduarda Leysen