Airbnb, Inc.

California Institute of Technology

Joseph Zadeh

Maxim Charkov

Riley Newman

Nathan Blecharczyk

Matt Weisinger

Niles A Pierce

Brian R Wolfe

Methods and systems for updating a calendar entry for an accommodation listing are disclosed. In one embodiment, the method comprises generating an availability model and an acceptance model for an accommodation listing in an accommodation reservation system and determining based on those models the probability that the accommodation listing would be able to be booked. Furthermore, the result of an accommodation search query can be filtered and/or sorted using the determined probability of booking.

Automated determination of booking availability for user sourced accommodations

Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium.

System and method for nucleic acid sequence design

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San Francisco, CA, United States of America

Joseph Zadeh