Cleveland State University

Joseph Wiencek

Michael Kalafatis

During the process of coagulation, prothrombin is activated to α-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

Recombinant prothrombin analogues and uses thereof

During the process of coagulation, prothrombin is activated to &#x3b1;-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for modulation of the activation of prothrombin. In certain embodiments, a recombinant prothrombin with at least one point mutation or deletion is provided.

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Cleveland, OH, United States of America

Joseph Wiencek