Smithkline Beecham Corporation

Smithkline Corporation

Smithkline Beckman Corporation

Progenra, Inc.

Other

The Children's Hospital of Philadelphia

Joseph Weinstock

David T Hill

Dimitri E Gaitanopoulos

Richard McCulloch Keenan

James Martin Samanen

Charles K Brush

John G Gleason

Carl Kaiser

Joseph A Finkelstein

Gerald R Girard

Suresh Kumar Kizhakkethil-George

Judith Hempel

Orum D Stringer

Kenneth G Holden

Feng Wang

Jian Wu

John Duncan Elliott

Jack Dale Leber

Blaine M Sutton

Robert Gene Franz

Saket Agarwal

Matthew P Kodrasov

Jia-Ning Xiang

Siegfried B Christensen, Iv

Katherine L Widdowson

Dennis Shinji Yamashita

Michael L Moore

Robert A Daines

Francis R Pfeiffer

Israil Pendrak

Benjamin Nicholson

Paul G Lysko

Michael R Palovich

Charles E Berkoff

Lendon Norwood Pridgen

Gregory Gallagher

James W Wilson

Hui Wang

Wayne W Hancock

David L Ladd

Mei Li

Susan C Shilcrat

Craig Leach

Balan Chenera

Virgil D Wiebelhaus

Pamela A Chambers

William Kingsbury

Judith Hampel

Mohamed K Mokhallalati

Genevieve F Sosnowski

Sarah Jane Paikowsky

Francis T Brennan

Hye-Ja Oh

Bruce Mico

Ping Cao

Method and compounds for treating cancer by, for example, modulating immune system activity, are provided.

Azole compounds as ubiquitin-specific protease USP7 inhibitors

Compounds and pharmaceutical compositions for treating cancer by, for example, modulating immune system activity, are provided.

Covalent irreversible inhibitors of USP7 as anti-cancer agents

Methods and compounds for treating cancer by, for example, modulating immune system activity, are provided.

Methods of treating cancer through the inhibition of USP7 and immune system modulation

Methods and compounds are disclosed for treating dry age-related macular degeneration, and preventing or delaying the onset of wet age-related macular degeneration.

Treatment of age-related macular degeneration

Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.

Anti-neoplastic compounds, compositions and methods

This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

IL-8 receptor antagonists

Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.

Endothelin receptor antagonists

This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.

Fatty acid synthase inhibitors

Macrophage scavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.

Macrophage scavenger receptor antagonists

Salicylanilide derivatives which are macrophagescavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.

Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases

Invented is a method of preparing combinatorial libraries and combinatorial libraries prepared thereby. Also invented is a method for identifying compounds having desired characteristics from a combinatorial library or a set of combinatorial libraries by the use of flow cytometry. Also invented is a method for encoding combinatorial libraries using fluorophore labeled beads.

Method of encoding a series of combinatorial libraries and developing structure activity relationships

Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.

Substituted imidazolyl-alkyethio-aldanoic acids

Compounds and methods

Substituted imidazolyl-alkylthio-alkanoic acids

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Phoenixville, PA, United States of America

Joseph Weinstock