Aronex Pharmaceuticals, Inc.

Joseph W Wyse

Charles D Warner

This invention discloses a novel cationic lipid acid salt of 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol. This invention further discloses a transmembrane compatible body suitable for transfection of animals and animal cells with nucleotides such as DNA, RNA, and synthetic nucleotides. Such transmembrane compatible bodies arise from hydratable non-liposomal halogenated solvent-free lyophilate comprising 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol and DOPE. This invention yet further discloses a halogenated solvent-free aqueous solution, suitable for lyophilization into a preliposomal powder, wherein the solution comprises 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol wherein substantially all 3.beta.�N-(N',N'-dimethylaminoethane)-carbamoyl!cholesterol is dissolved.

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The Woodlands, TX, United States of America

Joseph W Wyse