Smithkline Beecham Corporation

Other

Joseph W Venslavsky

William Edward Bondinell

Robert M DeMarinis

Thomas Wen-Fu Ku

John J Lafferty

William Henry Miller

Roderick Alan Porter

David Thomas Davies

Fadia E Ali

James Martin Samanen

Francis R Pfeiffer

Steven Dabbs

James A Chan

Dinubhai H Shah

Tobias Oregon Yellin

Raul Rolando Calvo

A method of treating a CCR5-mediated disease state in mammals which comprises administering to a mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Compounds and methods

This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.

Fibrinogen receptor antagonists

Alpha-adrenergic receptor antagonsists having the formula (I) as set forth below which are useful to produce alpha-adrenergic antagonism, pharmaceutical compositions thereof, and methods of treatment therewith are disclosed: ##STR1## The variables X, R, Y, Het and A are as defined in the specification.

Furo- and thieno[4,3,2-ef][3]benzazepines useful as alpha adrenergic

.alpha.-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonists to produce .alpha.-adrenoceptor antagonism in mannals.

.alpha.-adrenergic receptor antagonists

.alpha.-adrenoceptor antagonists having the formula: ##STR1## which are useful to produce .alpha.-adrenoceptor antagonism, pharmaceutical compositions including these antagonists, and methods of using these antagonist to produce .alpha.-adrenoceptor antagonism in mammals.

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Wayne, PA, United States of America

Joseph W Venslavsky