Denali Therapeutics Inc.

Joseph W Lewcock

Mark S Dennis

Xiaocheng Chen

Adam P Silverman

Rinkan Shukla

Do Jin Kim

Rishi Rakhit

Lesley Ann Kane

Suresh Poda

In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.

Anti-Tau antibodies and methods of use thereof

Growing community of inventors

South San Francisco, CA, United States of America

Joseph W Lewcock