Wisconsin Alumni Research Foundation

Joseph Vasquez

Helen Blackwell

Yiftah Tal Gan

Compounds provided are racemic, non-racemic or substantially enantiomerically pure dimers or salts or solvates thereof of formula:

Simplified structural mimetics of AIPS as quorum sensing inhibitors

Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular inare provided. Compounds provided are racemic, non-racemic or substantially enantiomerically pure cyclic peptides of formula I: or salts or solvates thereof, where variables R, W, X, X, and Z and are as described in the specification and Lis a divalent linker which contains 1-12 carbon atoms, optionally 1-4 oxygen atoms, optionally one or two carbon-carbon double bonds, and hydrogen atoms to satisfy valency. Certain dimers of the cyclic peptides are also provided. One or more cylic peptides or dimers thereof herein can be employed to inhibit QS and to thus inhibit virulence inbacteria. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful in treating infections ofbacteria. Methods for treating such bacterial infections are also provided.

Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular inare provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence inbacteria and in particular in. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections ofbacteria and in particular of. Methods for treating such bacterial infections are provided.

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Madison, WI, United States of America

Joseph Vasquez