Merck + Co., Inc.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Joseph V Bondi

Alice E Loper

Richard J Harwood

Edward M Cohen

Saul Yedgar

Yuval Cohen

Lucille A Grabowski

This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens.

Lipid-polymer conjugates, their preparation and uses thereof

A transdermal delivery system suitable for the drug (4aR-trans )-3,4,4a,5,6,10b-hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol over an extended period of time is described.

Transdermal delivery systems

A method and device for delivering acidic or basic drugs in a controlled delivery system is described.

pH-Mediated drug delivery system

A method and device for administering timolol for an extended period is described. By the method and device, transdermal application of timolol may be accomplished with substantially no irritation to the skin.

Transdermal system for timolol

Ocular inserts with or without pharmacologically active agents comprising low molecular weight polymers have a lower propensity to cause blurred vision compared with inserts prepared from high molecular weight hydroxypropyl cellulose. When an enteric coating material is included as a constituent of the matrix there is provided a means for controlling and predicting dissolution rates of the insert to yield a prolonged residence time.

Biosoluble ocular insert

A device for measuring diffusion, particularly adaptable to measuring diffusion of drugs, is described.

Diffusion measuring device

A drug delivery system designed to deliver water and drug to the site of administration is composed of a core of an aqueous solubulizing system in a wax housing, which melts at body temperature, surrounded by a matrix of drug and water-dispersible excipients. The entire unit may also be coated with a semi-permeable membrane to modulate drug release.

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Collegeville, PA, United States of America

Joseph V Bondi