Hoffmann-la Roche Inc.

Joseph Triscari

Waleed Danho

Jefferson Wright Tilley

Ann C Sullivan

James Guthrie Hamilton

Rolf Wagner

Lawrence D Tobias

Vincent Stewart Madison

Richard W Kierstead

John G Mullin

Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.

Analogs of tyrosine sulfate or tyrosine phosphate containing peptides

Intermediates for analogs of tyrosine sulfate or tyrosine phosphate

Cholecystokinin analogs useful for suppressing food intake in mammals and humans.

Cholecystokinin analogs for controlling appetite

Cyclic peptides with appetite regulating activity.

Cyclic peptides having appetite regulating activity

The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are 1-substituted imidazoles, 4-substituted imidazoles, 3-substituted pyridines, 3-substituted indoles, 4-substituted pyrimidines, 5-substituted tetrazoles, pyrazolidines, quinazolines, and substituted xanthene carboxylic acids.

Thromboxane synthase inhibitors as insulin lowering agents and

Compounds of the formula ##STR1## wherein R.sub.1 is ##STR2## the asterisk denotes the specific bonding orientation to the piperidine moiety; R.sub.2 is alkylene or --CO--(CH.sub.2).sub.n -- wherein n is 0 to 11; R.sub.3 and R.sub.4, independently, are hydrogen, halogen or lower alkoxy; and HET is pyridinyl, pyrimidinyl or imidazolyl, and salts thereof with pharmaceutically acceptable acids, are described. The compounds of formula I exhibit insulin lowering activity and are useful as antiobesity agents.

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Bloomfield, NJ, United States of America

Joseph Triscari