Medtronic Vascular, Inc.

Covidien LP

Medtronic Ardian Luxembourg S.a.r.l.

Joseph Traina

James Mitchell

Justin Peterson

Terry Morgan

Gerald N Hodgkinson

Christopher W Storment

Rudy Beasley

Daniel A Schulz-Jander

Michele Lee Silver

Stefan Stoyanov Tunev

Ayala Hezi-Yamit

Dishuan Chu

Carol M Sullivan

Susan Edwards

Brian Graham

Beth Sersen

Nathanael Glucklich

Lori Garcia

Rajen Kumar

Abby Schlichting

Salvador Avelar

William Heaton

Carol Sullivan

James E Mitchell

The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.

Drug eluting medical device

Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

Apparatus and methods for filling a drug eluting medical device via capillary action

Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

Apparatus and methods for loading a drug eluting medical device

Methods for loading a drug eluting medical device

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Napa, CA, United States of America

Joseph Traina