Wyeth

Wyeth Holdings Corporation

Joseph Thomas Rubino

Mark Edward Ruppen

Justin Keith Moran

Andrew George Popplewell

John W Simpson

Nitin Krishnaji Damle

Arthur Kunz

John Francis DiJoseph

Nishith Merchant

Eugene Joseph Vidunas

Neera Jain

Paul David Robbins

Victoria Siskavich

Maureen M Harrison

Pooja Gandhi

John McLean Simpson

Arthur Kuntz

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Calicheamicin derivative-carrier conjugates

This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.

CCI-779 formulations for parenteral administration

CCI-779 concentrate formulations

Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation contains CCI-779, an alcoholic co-solvent, and an antioxidant. Another parenteral formulation contains CCI-779, an alcoholic solvent, an antioxidant, a diluent solvent, and a surfactant. Processes for preparing parenteral CCI-779 formulations using a co-solvent concentrate are also provided.

Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and a surfactant

Growing community of inventors

Towaco, NJ, United States of America

Joseph Thomas Rubino