Merck Sharp + Dohme Corp.

Calixa Therapeutics, Inc.

Cubist Pharmaceuticals, Incorporated

Joseph Terracciano

Nicole Miller Damour

Giovanni Fogliato

Chun Jiang

Dario Resemini

Giuseppe Alessandro Donadelli

Valdas Jurkauskas

Jan-Ji Lai

Pradip M Pathare

Jian-Qiao Gu

Giuseppe Alessandron Donadelli

Kristos Adrian Moshos

You Seok Hwang

Yanmei Lan

Jonathan Cam Ly

Jianxun Zhou

Lisa Duong

Sanjay Mudur

Asli Ovat

Jason Woertink

This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.

Ceftolozane antibiotic compositions

Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.

Ceftolozane-tazobactam pharmaceutical compositions

Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam.

Novel solid forms of ceftolozane are described, as well as methods for the preparation and use of these solid forms.

Solid forms of ceftolozane

This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.

Tazobactam arginine compositions

Growing community of inventors

Concord, MA, United States of America

Joseph Terracciano