Southwest Research Institute

Joseph T Persyn

Joseph A McDonough

Darren E Barlow

Neal K Vail

Albert M Zwiener

Eliot Mark Slovin

James D Oxley

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates

The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state.

Dry to wet injector

Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents

Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

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Lakehills, TX, United States of America

Joseph T Persyn