Hoechst Roussel Pharmaceuticals

Hoechst Marion Roussel

Hoechst-roussel Pharmacueticals Inc.

Joseph T Klein

Richard C Effland

Larry A Davis

Gordon E Olsen

Lawrence L Martin

Kevin J Kapples

Brian S Freed

Russell R Hamer

David G Wettlaufer

Gregory M Shutske

Richard C Allen

John D Tomer, Iv

R Richard Hamer

Gordon E Olson

R Russell Hamer

Peter A Nemoto

There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.

Substituted pyridylamino indoles

This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.

Substituted aminothienopyridines, pharmaceutical composition and use

This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula ##STR1## wherein Q is S, N or NR.sub.2 ;

Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo [b

This invention relates to compositions of substituted pyridinylamino-1H-indoles of the formula ##STR1## wherein Q is N or NR.sub.2 ; Y is CH R.sub.1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; R.sub.2 is hydrogen or loweralkyl; R.sub.3 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen; and n is 0 or 1 with utility in the treatment of personality disorders as obsessive compulsive disorders.

A personality disorder treatment method and composition

There are described compounds of the formula ##STR1## where n is 0 or 1;

Certain nitro-3-pyrinamines and 3-oxy-analogues

There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.

Substituted (pyridinylamino)-indoles

Substituted pyridinylamino 1H-indazoles

This invention relates to 2,3-dihydro-1-(pyridinylamino)-indoles of the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, aryl, arylloweralkyl, alkenyl, alkynyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl or heteroaryl; the term heteroaryl signifying a group selected from pyridine or thiophene; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, or a pharmaceutically acceptable acid addition salt thereof or where appropriate, an optical, geometrical or stereoisomer or racemic mixture thereof. The compounds of this invention are useful as analgesics, anticonvulsants, and for the treatment of memory dysfunctions characterized by a cholinergic deficit.

Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as

Novel 2-(3-phenylpropyl)hydrazines, intermediates in and processes for the preparation thereof, and a method of treating personality disorders utilizing compounds or compositions thereof are disclosed.

Growing community of inventors

Bridgewater, NJ, United States of America

Joseph T Klein