Olatec Therapeutics LLC

Olatec Industries LLC

Chemic Laboratories, Inc.

Chemsmart, LLC

Jsb Pharma Development, LLC

Koda Therapeutics, LLC

Joseph St Laurent

Gerald S Jones

Scott A Goodrich

David M Bresse

George M Shopp

David M Breese

George Maguire

Described herein are compounds that act as antimicrobial agents, compositions comprising these compounds, and methods of their use in to treating infections caused by() or killing or inhibiting the growth of

Antimicrobial agents and compositions and uses thereof

Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.

Compositions comprising folic acid derivatives, their preparations and methods of use

The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

3-methanesulfonylpropionitrile for treating inflammation and/or pain

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

Pharmaceutical composition for treating inflammation and pain

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and &#x3c9;-(methylsulfonyl)alkylamine or &#x3c9;-(methylsulfonyl)alkylamide. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering &#x3c9;-(methylsulfonyl)alkylamine or &#x3c9;-(methyl sulfonyl)alkylamide, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

Pharmaceutical composition

The present invention relates to purified compounds of 3-methanesulfonylpropionitrile, in which at least one of the hydrogen, oxygen, sulfur, and nitrogen atoms is substituted with a respective isotope that includes, but not limited toH (deuterium),H (tritium),C,C,N,O,O, andS. The purified compound has at least 90% purity. Preferred compounds are deuterated 3-methanesulfonylpropionitriles.

Deuterated 3-methanesulfonylpropionitrile

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-benzylsulfonylpropionitrile, or its pharmaceutically acceptable salts. The present invention also relates to methods of using the compound for treating inflammation or inflammatory-related disorders and pain.

Pharmaceutical use of 3-benzylsulfonylpropionitrile

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering &#x3c9;-(methylthio)alkylnitriles such as 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3-benzylsulfonylpropionitrile, in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder. Topical administration and oral administration are preferred route of administration.

The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 4-benzylsulfonyl-2-butenenitrile, or a pharmaceutically acceptable salt or solvate thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 4-benzylsulfonyl-2-butenenitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

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Lakeville, MA, United States of America

Joseph St Laurent