Novo Laboratories, Incorporated

Novo Enzyme Corporation

Joseph Spina

Michael K Weibel

An enzymatic intralenticular cataract treatment for removal of nuclear cortical and subcapsular regions of the cataractous lens through enzymatic digestion thereof which comprises introduction of a concentrated solution of a trypsin enzyme into the nuclear and cortical regions of a cataractous lens, and after enzymatic digestion removing the liquefied cataractous material. The procedure allows subsequent removal of the nuclear, cortical and subcapsular portions of a cataractous lens through a very tiny incision in the eye and lens capsule, leaving all other structures within the eye intact. Bovine and porcine trypsins are preferred.

Intralenticular cataract surgery

An enzymatic intralenticular cataract treatment method for removal of nuclear cortical and subcapsular regions of the cataractous lens through enzymatic digestion thereof, which comprises introduction of a concentrated solution of proteinase into the nuclear and cortical regions of a cataractous lens by way of a cannula inserted through a very tiny incision in the cornea and puncture opening into the lens capsule, leaving all other structures within the eye intact, after which a gas bubble is introduced from the cannula into the lens, the gas bubble serving to maintain the enzyme compartmentalized within the subcapsular region. As illustrated in FIG. 4, a preferred embodiment of the apparatus involved with the method comprises an enzyme reservoir connected through a delivery means and a four port, two channel valve to a cannula. The cannula is filled with enzyme solution then the delivery means and valve are operated by the surgeon so as to carry out the above described treatment method.

Delivery apparatus and method for treatment of intralenticular cataracts

An enzymatic intralenticular cataract treatment for removal of nuclear cortical and subcapsular regions of the cataractous lens through enzymatic digestion thereof which comprises introduction of a concentrated solution of mixed exogenous enzymes into the nuclear and cortical regions of a cataractous lens, and after enzymatic digestion removing the liquefied cataractous material. The procedure allows removal of the nuclear, cortical and subcapsular portions of a cataractous lens through a very tiny incision in the eye and lens capsule, leaving all other structures within the eye intact.

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Bryn Mawr, PA, United States of America

Joseph Spina