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Pharmos Corporation

Technion Research & Development Foundation Ltd

Joseph Schwartz

Doron Friedman

Haim Aviv

Shimon Amselem

Josef Rom

Israel Alterman

The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.

Topical and transdermal delivery system utilizing submicron oil spheres

The invention relates to an oil-in-water emulsion and related method for administration of a drug to a mucosal surface. The emulsion has an aqueous continuous phase and a plurality of submicron particles having an average particle diameter of from 10 nm to 600 nm, with the particles having a hydrophobic core of a fat or oil which is surrounded by a surfactant layer. The emulsion further includes a drug and a mucoadhesive polymer which is a polymer or copolymer of acrylic acid or methacrylic acid, a poly(methyl vinyl ether/maleic anhydride) copolymer, pectin, alginic acid, hyaluronic acid, chitosan, gum tragacanth, karaya gum or carboxymethylcellulose. The hydrophobic core has less than 1% (w/w) protein, relative to the weight of the hydrophobic core, and the emulsion contains less than 5% (w/w) surfactant, relative to the weight of the hydrophobic core.

Bioadhesive emulsion preparations for enhanced drug delivery

The method of converting clayey or silty soil into stable and solid underground columns or piles suitable for carrying a building structure, comprises first the drilling of bores of a diameter considerably smaller than the external diameter of the column or pile to be created, to a predetermined depth, and secondly directing a focused laser beam gradually across the entire surface of each bore by mechanical and optical means, in such a manner that each point of the bore surface is irradiated and heated at an intensity sufficient for converting the soil surrounding the bore into a solid permanent mass of a predetermined thickness measured from the bore surface, which mass retains its strength and is resistant to moisture and temperature.

Formation of load-bearing foundations by laser-beam irradiation of the

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Rehovot, Israel

Joseph Schwartz