Modernatx, Inc.

Joseph Schariter

Luis Brito

Orn Almarsson

Kimberly Hassett

Mike Smith

Stephen G Hoge

Michael H Smith

Charles Bowerman

Yan Xia

The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

Methods of making lipid nanoparticles

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins.

RNA formulations

Growing community of inventors

Cambridge, MA, United States of America

Joseph Schariter