Oregon State University

Schering Aktiengesellschaft

E-msion, Inc.

Joseph S Beckman

Valery G Voinov

Douglas F Barofsky

Max L Deinzer

James Hurst

John Sirois

Chris Beaudry

Roland Neuhaus

Thorsten Blume

Detlev Suelzle

Charles Otis

Iris Pribilla

Tory M Hagen

William M Freund

Yury Vasil'ev

Gisbert Depke

Wei Kong

Pamela R Beilby

Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.

Therapeutic metal complexes and ligands and methods of making and using the same

Reflectron-electromagnetostatic cells for use in mass spectrometers are provided herein that cause ion packets to pass through the cell a plurality of times during fragmentation.

Reflectron-electromagnetostatic cell for ECD fragmentation in mass spectrometers

Mass spectrometry cells include one or more interleaved magnetostatic and electrostatic lenses. In some examples, the electrostatic lenses are based on electrical potentials applied to magnetostatic lens pole pieces. In other alternatives, the electrostatic lenses can include conductive apertures. Applied voltages can be selected to trap or transport charged particles, and photon sources, gas sources, ion sources, and electron sources can be provided for various dissociation processes.

Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers

An electron source for electron-induced dissociation in an RF-free electromagnetostatic cell for use installation in a tandem mass spectrometer is provided. An electromagnetostatic electron-induced dissociation cell may include at least one magnet having an opening disposed therein and having a longitudinal axis extending through the opening, the magnet having magnetic flux lines associated therewith, and an electron emitter having an electron emissive surface comprising a sheet, the emitter disposed about the axis at a location relative to the magnet where the electron emissive surface is substantially perpendicular to the magnetic flux lines at the electron emissive surface.

Electron source for an RF-free electronmagnetostatic electron-induced dissociation cell and use in a tandem mass spectrometer

Certain disclosed embodiments concern a method and an apparatus for determining molecular structure. One embodiment comprises producing sample ions from a sample, cooling molecules of the sample ions by either embedding sample ions in superfluid droplets, such as superfluidic helium droplets, or subjecting sample ions in a cooled ion trap, to a selected temperature approaching absolute zero. Plural cooled sample ions confined in a diffraction zone are oriented using a laser, and a diffraction image is produced from oriented sample ions using an electron beam. Molecular structure is determined using collected images from different orientations obtained under different polarization directions of the orientation laser. Embodiments of an apparatus for determining molecular structure also are disclosed. The apparatus operation, data accumulation and processing are controlled by software. The software can directly calculate electron density maps without using heavy atom derivatives or multi-wavelength anomalous dispersion phasing methods.

Apparatus and method for determining molecular structure

The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.

Aromatic sulfonamides as peroxynitrite-rearrangement catalysts

Growing community of inventors

Corvallis, OR, United States of America

Joseph S Beckman