Smithkline Beecham Corporation

Smithkline Beckman Corporation

Joseph Robert Flisak

Ivan Lantos

Wilford L Mendelson

Paul G Gassman

Stephen T Ross

Clifford S Labaw

Albert Stephen Kearney

Li Liu

Cherng-Yih Perng

Nagesh Palepu

This invention relates to a new monoargininyl salt form of the endothelin receptor antagonist (E)-3-&lsqb;1-n-Butyl-5-&lsqb;2-(2-carboxyphenyl)methoxy-4-chlorophenyl&rsqb;-1H-pyrazol-4-yl&rsqb;-2-&lsqb;(5-methoxy-2,3-dihydrobenzofuran-6-yl)methyl&rsqb;-prop-2-enoic acid.

(E)-3-&lsqb;1-n-Butyl-5-&lsqb;2-(2-carboxyphenyl)methoxy-4-chlorophenyl&rsqb;-1H-pyrazol-4-yl&rsqb;-2-&lsqb;(5-methoxy-2,3-dihydrobenzofuran-6-yl)methyl&rsqb;-prop-2-enoic acid monoargininyl salt

This invention relates to a process for preparing eprosartan by reacting 4-&lsqb;(2-n-butyl-5-formyl-1H-imidazol-1-yl)methyl&rsqb;benzoic acid or the bisulfite addition compound of 4-&lsqb;(2-n-butyl-5-formyl-1H-imidazol-1-yl)methyl&rsqb;benzoic acid with (2-thienylmethyl)propanedioic acid, mono-ethyl ester.

Process for preparing eprosartan

Synthesis of acid addition salts of hydroxylamines

This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.

Intermediates for preparing epoxy esters

Process for preparation of epoxy esters and intermediates prepared

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Lansdale, PA, United States of America

Joseph Robert Flisak