Smithkline Beckman Corporation

Smithkline Corporation

Joseph R Valenta

Marcia C Shearer

David J Cooper

Kenneth M Snader

Robert D Sitrin

Betty A Bowie

David J Newman

Claude H Nash, Iii

Thomas O Lindsey

Richard D Hedde

Francis E Wdzieczkowski

George W Gebhardt

A novel antibiotic complex of 'vancomycin-like' antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.

Antibiotics produced by Kibdelosporangium aridum Shearer gen. nov., sp.

A novel antibiotic complex of 'Vancomycin-like' antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.

Antibiotics produced by Kibdelosporangium aridum shearer

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by streptosporangium fragile

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by Streptosporangium fragilis Shearer

A liquid fraction collector has a first series of containers and a second series of containers, each of the first and second series of containers being arranged in a plurality of groups with means to support each group at a different elevation. A conduit leads upwardly from each container in said first series with the upper ends of the conduits lying in a first row and a conduit leads upwardly from each container in said second series with the upper end of the conduits lying in a second row parallel to the first row. A carriage is mounted above said conduits. The carriage has means to discharge a liquid having an inverted V guide member with one trough over one row and the other trough over the other row and a discharge tube having its discharge end movable from a position over one trough of the guide member to a position over the other trough of the guide member. The carriage is advanced stepwise from one conduit to the next above the said rows from one end of rows to the other end and returned to said one end by moving means. The discharge tube discharges into the conduits of one row as the carriage advances and is moved to cause discharge into the conduits of the other row when the carriage returns by adjusting means.

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Strafford, PA, United States of America

Joseph R Valenta