The Dow Chemical Company

Richard K. Frank

Joseph R. Garlich

David A. Wilson

Jaime Simon

Kenneth Mcmillan

David E. Troutner

Joseph R Garlich

David A Wilson

R Keith Frank

Kenneth McMillan

Garry E Kiefer

William Jack Kruper, Jr

William A Fordyce

Roberta C Cheng

David E Troutner

Tipton T Masterson

William F Goeckeler

Richard Keith Frank

Wynn A Volkert

Vidyadhar Babu Hegde

Davis A Wilson

William F Goeckleler

Sharon Braughman

Sharon Baughman

William F Goeckler

Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially .sup.153 samarium-ethylenediaminetetramethylenephosphonic acid, which optionally contains a divalent metal ion, e.g. calcium, and is frozen, thawed, and then administered by injection.

Frozen radiopharmaceutical formulations

A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.

Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic

Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.

Bicyclopolyazamacrocyclophosphonic acid half esters

Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast

A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.

Conjugates possessing ortho ligating functionality

Conjugates possessing ortho ligating functionality and complexes thereof

A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.

Macrocyclic ligands and complexes

A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.

Macrocyclic congugates and their use as diagnostic and therapeutic agents

A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The chelants possess the general formula ##STR1## wherein R.sup.'1, R.sup.'2, R.sup.'3, R.sup.'4, R.sup.'5 and R.sup.'6, Z' and X are all defined in the specification. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.

Complexes possessing ortho ligating functionality

Compositions and method for therapeutic and/or diagnostic treatment of soft tissue tumors in mammals using certain metals ions that are particle-emitting radionuclides, e.g. .sup.153 Sm, complexed with a phenolic carboxylate ligand, e.g. 2,6-bis[N,N-bis(carboxymethyl)aminomethyl]-4-(acetamido)phenol, (bis-IDA), is described.

Radioactive compositions for soft tissue tumors

Oral compositions and methods effective in promoting oral hygiene containing in an effective amount at least one cyclic alkylamine or cyclic amine as an antiplaque and/or antigingivitis agent.

Oral compositions for inhibiting plaque formation

Oral compositions containing an effective amount as an anticalculus agent at least one cyclic alkylamine or cyclic amine in the presence or absence of a cationic antimicrobial agents.

Oral compositions for inhibiting calculus formation

A method for therapeutic and/or diagnostic treatment of soft tumor carcinoma in mammals using certain metals or particle-emitting radionuclides complexed with hydroxyethylethylenediaminetriacetic acid is described.

Method of treating and/or diagnosing soft tissue tumors

Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors or the relief of bone pain in animals.

Organic amine phosphonic acid complexes for the treatment of calcific

Oral compositions containing phytic acid or a physiologically acceptable salt thereof, a cationic antimicrobial compound and a compatibilizing agent are disclosed for controlling dental calculus, dental plaque, gingivitis, periodontitis and/or oral malodor.

Growing community of inventors

Lake Jackson, TX, United States of America

Joseph R Garlich