The General Hospital Corporation

Massachusetts Institute of Technology

Children's Medical Center Corporation

The Charles Stark Draper Laboratory, Inc.

Other

Children's Hospital

Harvard College

University of Massachusetts

Massachusetts Eye and Ear Infirmary

Forsyth Dental Infirmary for Children

Vbi Technologies, L.l.c.

Cambridge Childern's Medical Center Corproration

Vacanti, Joseph P.

Langer, Robert S.

Joseph P. Vacanti

Joseph P Vacanti

Jeffrey T Borenstein

Robert Samuel Langer

Eli J Weinberg

Charles Alfred Vacanti

Mohammad Reza Kaazempur-Mofrad

David M Hoganson

Kevin R King

Antonios Georgios Mikos

Osamu Ishii

Alexander Sevy

Chiao-Chun Wang

Howard I Pryor

Toshiraru Shin'oka

Christopher K Breuer

Young-Moon Michael Shin

Tomoyuki Maemura

Jennifer Ogilvie

Georgios Sarakinos

Linda G Griffith

Ira Spool

Linda G Cima

Keith T Paige

Yi Lin Cao

Joseph Upton

Robert S Langer

Michael John Cima

David J Mooney

Patricia K Donahoe

David J Carter

Martin P Vacanti

Robert H Rubin

David T MacLaughlin

Peter T Masiakos

Beverly E Chaignaud

Brian K Orrick

Eleanor M Pritchard

Edward J Barnard

Nicholas J Krebs

Berverly E Chaignaud

Theodore Marentis

Wing Cheung

Donald Elliot Ingber

Anthony Atala

Christine E Schmidt

Peter T Lansbury

Venkatram R Shastri

Bjorn R Olsen

Michael R Freeman

Erik Bassett

Cathryn Sundback

Mark Randolph

Theresa A Hadlock

Irina Pomerantseva

Hidetomi Terai

Pamela C Yelick

Mack Cheney

Phillip Stashenko

John D Bartlett

Denise Barrera

Lynt Johnson

Linda Griffith-Cima

Charles A Vacanti

Eli The Charles Stark Draper Lab Inc Weinberg

Osamu Ishi

A platform for creating engineered tissues includes a vascular tube that defines a vascular diameter and is configured to receive vascular system seed cells, a non-vascular tube that defines a non-vascular tube diameter and is configured to receive organ system seed cells, and a barrier formed between the vascular tube and the non-vascular tube.

Systems for and methods for using biomimetic structures providing communication in living tissue

A platform for creating engineered tissues includes a vascular tube that defines a vascular diameter and is configured to receive vascular system seed cells, a non vascular tube that defines a non-vascular tube diameter and is configured to receive organ system seed cells, and a barrier formed between the vascular tube and the non vascular tube.

The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

Biomimetic vascular network and devices using the same

The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on the other side by a smooth muscle cell layer, wherein said model is susceptible to the extravasation of red blood cells across said porous membrane due to drug induced vascular injury.

System and method for in vitro blood vessel modeling

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Fabrication of vascularized tissue using microfabricated two-dimensional molds

The present invention provides for compositions and constructs for craniofacial reconstruction implants, and methods for making and using same. Specific embodiments provide for a biocompatible scaffold having an auricular shape and a permanent bendable framework within the scaffold, wherein the permanent bendable framework allows deformation and return to pre-deformation shape, and thus maintains the auricular shape of the scaffold.

Engineered craniofacial constructs with composite scaffold

The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography ('nanotopography') for use in modulating the organization and/or function of multiple cell types.

Nanotopographic compositions and methods for cellular organization in tissue engineered structures

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.

Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.

Micromachined bilayer unit of engineered tissues

The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.

Microfabricated compositions and processes for engineering tissues containing multiple cell types

Growing community of inventors

Winchester, MA, United States of America

Joseph P Vacanti