Warner-lambert Company

Other

Joseph P Sanchez

John Michael Domagala

Bharat Kalidas Trivedi

Gary Louis Bolton

Thomas F Mich

Edward Faith Elslager

Rocco Dean Gogliotti

Terri Stoeber Purchase

Rajeshwar Singh

Susan E Hagen

Michael Andrew Stier

Ashok K Trehan

Ronald G Micetich

Edmund Lee Ellsworth

Brian Morgan Watson

Dai Q Nguyen

Howard Daniel Hollis Showalter

Townley P Culbertson

Tuan Phong Tran

Judy Yip

Liren Huang

Paul Bird

Maureen Elizabeth Carey

Albert Kudzoi Amegadzie

Marjorie S Solomon

Arkadii Vaisburg

Theodore H Haskell

Dietrich Schweiss

Susan E Prugh

Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: Rand Rinclude alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, and heteroaryl; R, R, and Rinclude H, alkyl, alkoxy, halo, NO, CN, NH, alkyl and dialkylamino; Rincludes hydrogen, alkyl, cycloalkyl, heterocyclic, fused heterocyclic, aryl and fused aryl; J and K are C or N; and pharmaceutically acceptable salts thereof. 

3-aminoquinazolin-2,4-dione antibacterial agents

Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: Rand Rinclude alkyl, alkenyl, cycloalkyl, aryl, hetero-cyclic, and heteroaryl; R, R, and Rinclude H, alkyl, alkoxy, halo, NO, CN, NH, alkyl and dialkylamino; Rincludes hydrogen, alkyl, cycloalkyl, hetero-cyclic, fused heterocyclic, aryl and fused aryl; J and K are C or N; and pharmaceutically acceptable salts thereof. 

Benzo&lsqb;de&rsqb;isoquinoline-1,3-diones which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents are described as well as methods for their preparation and formulation. Novel intermediates useful in the preparation of the final products are also described.

Isoquinolones

Benzo&lsqb;de&rsqb;isoquinoline-1,3-dione of Formula

Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Isothiazolones and pharmaceutical formulations

Isothiazolones

Ornamentation for a baseball glove

Isothiazolone compounds

Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Antibacterial agents - II

A novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections.

Antibacterial agents

Novel 7-piperazine derivatives of 5-amino- and 5-hydroxy-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents

The novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections.

The novel (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1, 8-n phthyridine-3-carboxylic acid, lower alkyl esters and pharmaceutically acceptable salts thereof are described as well as a method for its manufacture, formulation, and use in treating bacterial infections.

(S)-7-(3-amino-1-pyrrolidinyl)-1-cyclop

Growing community of inventors

Canton, MI, United States of America

Joseph P Sanchez