Bend Research, Inc.

Msd Consumer Care, Inc.

Pharmacia Corporation

Joseph P Reo

Dwayne Thomas Friesen

Leah Elizabeth Appel

Mohammed A Kabir

Jiansheng Wan

Sanjay Konagurthu

David Monteith

Edward Dennis LaChapelle

Richard Frank Falk

Ernest J Lee

Alice C Martino

Robert T Nowak

Malaz A Abutarif

Glenn E Fritz

John O'Mullane

John M Heimlich

Loksidh D Ganorkar

Gregory E Amidon

Robert M Noack

Connie J Skoug

John O'mullane

The invention discloses a pharmaceutical composition comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is for oral administration wherein the composition delivers phenylephrine or a pharmaceutically acceptable salt thereof via absorption in the colon. The pharmaceutical composition comprises a core comprising phenylephrine or a pharmaceutically acceptable salt thereof and an erodible layer which is in a time-dependent, pH-dependent, or colon-specific enzyme-dependent erodible layer that degrades to expose the core to release phenylephrine in the colon. In one preferred embodiment, the erodible layer encases the core. The composition optionally further comprises phenylephrine in the erodible layer or other additional layer(s). The pharmaceutical composition can further comprise one or more additional therapeutically active agents selected from one or more of the group consisting of antihistamines, analgesics, anti-pyretics, and non-steroidal anti-inflammatory agents. The invention also discloses methods of administering phenylephrine via the colon, thereby increasing the bioavailable amount of therapeutically active unconjugated phenylephrine relative to the total phenylephrine in the plasma.

Phenylephrine pharmaceutical formulations and compositions for colonic absorption

A pharmaceutical composition comprises multiparticulates comprising a drug, a matrix material, and swelling agent. In one aspect, the multiparticulates comprise a core comprising a drug, and a coating surrounding the core. The coating is selected from the group consisting of (i) a water-permeable, substantially drug-impermeable coating, and (ii) an anti-enteric coating.

Taste-masked drugs in rupturing multiparticulates

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Lakeland, TN, United States of America

Joseph P Reo