E. R. Squibb Sons, Inc.

Bristol-myers Squibb Compnay

Joseph O'Sullivan

Donald R Kirsch

Carol A Aklonis

Pushpa Singh

John E McCullough

Adrienne A Tymiak

Douglas W Phillipson

Janice H Del Mar

Edward Meyers

Peter H Ermann

Henner Straub

John E Leet

Stephen W Mamber

Jerry S Wells

Jessica A Gorman

Gordon W Robinson

J Scott Wells

Helen A Ax

Ascosteroside, obtainable by cultivation of a strain of Ascotricha amphitricha A.T.C.C. No. 74237, analogs thereof and salts and prodrugs of these compounds. The compounds have antifungal activity for use in a method for treating and preventing a fungal infection. Further, the compounds are useful in a method for inhibiting fungal growth.

Ascosteroside and analogs thereof useful in antifungal compositions for

A novel antibiotic substance, Scopularin, is prepared by cultivation of a strain of the microorganism, Scopulariopsis, A.T.C.C. No. 20,914. This compound and its alcohol derivative have also been found to have cytochrome P450 inhibition activity.

Scopularin

Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.

4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof

A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.

Gram-positive and gram-negative antibacterial compounds from the

Cultivation of a strain of the microorganism Dactylosporangium sp. A.T.C.C. No. 53693, yields the antibiotic substance EM5586 which contains the novel useful components dactylocycline A and dactylocycline B.

Dactylocycline A and dactylocycline B

Cultivation of a strain of the microorganism, Preussia sp., that has been deposited in the American Type Culture Collection as A.T.C.C. No. 20,923, yields a novel antibiotic substance, culpin, that has activity against a selected spectrum of microorganisms.

Culpin

4-Diazo-3-methoxy-2,5-cyclohexandien-1-one, and pharmaceutically acceptable salts thereof, are antibiotics having antibacterial activity against a variety of gram positive and gram negative bacteria, particularly against anaerobic bacteria. The compound can be prepared by culturing aerobically Penicillium funiculosum A.T.C.C. No. 20783 in a culture medium containing assimilable sources of carbohydrates and nitrogen.

4-diazo-3-methyl-2,5-cyclohexadine-1-one and pharmacetically acceptable

A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A.T.C.C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.

Antibiotic prepared from lysobacter sp. SC 14,067 and analogs thereof

A compound having the formula ##STR1## can be prepared by enzymatically coupling a compound of the formula ##STR2## with a compound of the formula ##STR3## in the presence of Escherichia coli acylase at a pH of from about 4.0 to about 6.0.

Process for preparing (3S)-3-[[[2-(protected or unprotected

Plastatin, an inhibitor of the enzyme phospholipase A.sub.2, can be prepared by cultivating Penicillium chermesinum under submerged aerobic conditions.

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Belle Mead, NJ, United States of America

Joseph O'Sullivan