Eli Lilly and Company

Joseph Matthew Colacino

Joseph Chiou-Chung Tang

John E Munroe

William Joseph Hornback

Louis Nickolaus Jungheim

Wayne A Spitzer

Frantz Victor

Shawn Christopher Miller

Mark Joseph Tebbe

Beverly Ann Heinz

Scott C Mauldin

Kirk Alan Staschke

Mark Ayer Muesing

Steven Duane Hatch

Anti-viral method

The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.

Inhibition of viral replication

A series of benzimidazole compounds having the following general structure are provided which inhibit the growth of picornaviruses (e.g., rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus) and flaviviruses (e.g., hepatitis C and bovine diarrheal virus). ##STR1## A method for inhibiting picornaviruses and flaviviruses is also provided which includes administering to a host an effective amount of the inventive benzimidazole compounds.

Anti-viral compound

The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus and flaviviruses such as hepatitis C and bovine diarrheal virus.

Anti-viral compounds

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Indianapolis, IN, United States of America

Joseph Matthew Colacino