University of California

Ionis Pharmaceuticals, Inc.

Joseph M Tuscano

Punit P Seth

Michael Oestergaard

Shuling Guo

Robert T O'Donnell

Nitin Nitin

Derick H Lau

Noriko Satake

Yunpeng Ma

The present disclosure provides compounds comprising modified oligonucleotides and anti-CD22 antibodies. Certain such modified oligonucleotides conjugated to anti-CD22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.

Antisense compounds and uses thereof

The present invention provides compositions comprising the component of fermented wheat germ extract ('FWGE') active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors, and methods of making and using such compositions. The active component from FWGE comprises polypeptides having a molecular weight in the range of about 5-100 kiloDaltons (kD), for example, a molecular weight in the range of about 12-50 kD. Exemplary polypeptides from FWGE determined to be active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors are listed in Table 1.

Fermented wheat germ proteins (FWGP) for the treatment of cancer

Growing community of inventors

Davis, CA, United States of America

Joseph M Tuscano