Mesoscale Technologies, Llc.

Westinghouse Electric Corporation

Westinghouse Electric Company LLC

Joseph M Leginus

Eli N Glezer

Bandele J Jeffrey-Coker

Jonathan K Leland

Mark A Billadeau

Sriram Jambunathan

Koustubh A Phalnikar

Jeff D Debad

Jeffery D Debad

Noe E Rodriguez, Ii

Daryl S Mileaf

Richard M Young

James H Deoms

Richard C Kapraun

Kevin E LaCour

Scott D Johnson

Eli N Glazer

Eli Glazer

Jambunathan Sriram

Jeffrey-Coker Bandele

Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

Assay cartridges and methods of using the same

An assay device for detecting the presence of analytes in an unknown sample including a reaction system wherein storage reservoirs containing reagent are fluidly connected to a track containing the sample. An actuation mechanism forces the reagent from the reservoirs and into the track where it mixes the reagents together and then with the sample at a first flow rate. The mechanism then reduces the force on the reagent to allow a second flow rate less then the first flow rate to force the reagent and sample mixture through the track so that reaction can occur, whereby a determination as to whether the target analyte was present may be made.

Disposable optical agglutination assay device and method for use

A method of detecting the presence and amount of a nitrate ester of a polyol in an unknown comprises preparing an antigen based on such an ester and using that antigen to raise antibodies for use in a biochemical assay for the nitrate ester. A preferred antigen is pentaerythritol trinitrate bonded to a protein such as thyroglobulin or BSA. Antibodies can be raised against this antigen in rabbits or other normally used laboratory animals, and the antibodies are used in, for example, a competitive inhibition enzyme immunosorbent assay (CIEIA).

Method of detecting nitrate esters

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Silver Spring, MD, United States of America

Joseph M Leginus