Emory University

Joseph M Kinkade, Jr

Alfred H Merrill, Jr

Victoria L Stevens

Jan Pohl

Ngoc-Anh Le

W Virgil Brown

Peter E Jensen

Raymond Shapira

This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other modification, e.g. chloro-tyrosine, dityrosine). Emphasis is given herein on oxidized sulfur- or selenium-containing amino acids (SSAA). The biomarker of oxidative stress in proteins may be detected with an antibody that binds to oxidized amino acids, specifically oxidized sulfur- or selenium-containing amino acids. The antibody may be monoclonal or polyclonal. The presence of biomarker or amount of biomarker present in a sample may be used to aid in assessing the efficacy of environmental, nutritional and therapeutic interventions, among other uses.

Biomarkers for oxidative stress

A method and composition for enhancing biological response modifiers, such as promoting cellular differentiation, by using a Vitamin A or an analog thereof and sphingosine or an analog thereof.

Method of modifying cellular differentiation and function and

A method and composition for enhancing the action of biological response modifiers, such as promoting cellular differentiation, by using Vitamin A or an analog thereof and sphingosine or an analog thereof.

Growing community of inventors

Decatur, GA, United States of America

Joseph M Kinkade, Jr