Leland Stanford Junior University

The United States Government as Represented by the Department of Veterans Affairs

Joseph M Castellano

Anton Wyss-Coray

Martin S Angst

Saul A Villeda

Jian Luo

Jinte Middeldorp

Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.

Methods and compositions for treating aging-associated conditions

Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.

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Tuckahoe, NY, United States of America

Joseph M Castellano