Sanraku-ocean Co., Ltd.

Panlabs, Inc.

Joseph Lein

Tomoyuki Ishikura

Kageaki Kouno

Kazuhiko Okamura

Yasushi Okumura

Yasuo Fugakawa

Yasuo Fukagawa

Yasutaka Shimauchi

Shoji Hirata

A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.

Antibiotics, neoviridogriseins, and their method of production

A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl, and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.

Antibiotics and derivatives thereof having .beta.-lactamase inhibitory

Streptomyces culture

A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.

Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory

Growing community of inventors

Fayetteville, NY, United States of America

Joseph Lein