Pfizer Corporation

Ignite Immunotherapy, Inc.

Joseph John Binder

Karin Ute Jooss

Helen Kim Cho

Brian Gregory Pierce

Van To Tsai

Joyce Tsi Tan

Michael Robert Dermyer

Siradanahalli Guru

Kenneth Nelson Wills

Paul Jason Cockle

Derek John Falconer

Marianne Marcela Andrea Martinic

David H Kirn

James Richard Merson

Michael Dale Eisenbraun

Douglas Hanahan

Liliana Maruri Avidal

Clare Lees

The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus; and compositions comprising the replication-competent, recombinant oncolytic vaccinia virus. The present disclosure also provides use of the vaccinia virus or composition for inducing oncolysis in an individual having a tumor.

Recombinant vaccinia virus and methods of use thereof

The present disclosure provides (a) vectors comprising a multi-antigen construct encoding two, three, or more immunogenic PAA polypeptides; (b) compositions comprising the vectors, (c) methods relating to uses of the vectors and compositions for eliciting an immune response or for treating prostate cancers.

Vectors for expression of prostate-associated antigens

The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

Prostate-associated antigens and vaccine-based immunotherapy regimens

The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

Cancer vaccines

Growing community of inventors

San Diego, CA, United States of America

Joseph John Binder