University of Pennsylvania

University of Illinois

Joseph J Mitala

Brett R Goldsmith

Alan T Johnson

Bohdana Marie Discher

Stephen G Sligar

Timothy H Bayburt

Ye Lu

Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.

Graphene-biomolecule bioelectronic devices

The present invention provides biomimetic sensor devices that utilize proteins&#x2014;such G-protein coupled receptors&#x2014;and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors

The present invention provides biomimetic sensor devices that utilize proteins&#x2014;such as G-protein coupled receptors&#x2014;and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.

Growing community of inventors

Rockville, MD, United States of America

Joseph J Mitala