Sk&f Lab Co.

Imperial Chemical Industries Limited

Smithkline Corporation

Ici Americas, Inc.

Joseph J Lewis

Robert L Webb

Diane A Trainor

Cyrus J Ohnmacht

Ying K Yee

George R Wellman

Richard A Wildonger

Philip D Edwards

Bing L Lam

Charles W Perkins

John E Trei

Compounds of formula I, Ia or Ib and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.

Piperidine derivatives

Compounds of formula I, Ia or Ib and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof; ##STR1##

Piperidine derivatives, compositions and use

The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R.sup.4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.

Heterocyclic ketones

A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.

Imidazolemethylphosphonium salts

A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.

Process for preparing 4-substituted imidazole compounds

A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.

Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole

Methods and compositions for increasing the feed efficiency of ruminant animals using 2,3-dibromopropanol as an active ingredient. The method comprises administering the active ingredient orally to growing ruminant animals in quantities sufficient to induce inhibition of methanogenesis in the rumen.

Growing community of inventors

West Chester, PA, United States of America

Joseph J Lewis