Research Development Foundation

Joseph J Hoffmann

Charles Joel Arntzen

David T Bailey

Jordan U Gutterman

Mary E Blake

Gamini S Jayatilake

The invention provides saponin mixtures and compounds which are isolated from the speciesand methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

Triterpene compositions and methods for use thereof

The invention provides novel saponin mixtures and compounds which are isolated from the species and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.

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Tucson, AZ, United States of America

Joseph J Hoffmann