American Cyanamid Company

Joseph J Goodman

David P Labeda

Donald B Borders

Guy T Carter

Raymond T Testa

William M Maiese

Michael Greenstein

John H Martin, Deceased

Taikwang M Lee

John H Martin

Gerhard Schlingmann

This invention relates to antibiotic LL-D37187.alpha. derived from the microorganism Streptomyces which is useful as an antibacterial agent.

Antibiotic LL-D37187.alpha.

The invention provides antibiotics designated LL-E19020 Epsilon and LL-E19020 Epsilon.sub.1 which are derived from the microorganism Streptomyces lydicus ssp. tanzanius NRRL 18036.

Antibiotics LL-E19020 Epsilon and LL-E19020 Epsilon.sub.1

This disclosure describes novel antibacterial agents designated LL-E10985.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.zeta. and LL-E19085.eta., having the structure: ##STR1## their production by aerobic fermentation of a new subspecies of Micromonospora citrea NRRL 18351 and mutants thereof, and the isolation and purification thereof.

Subspecies of Micromonospora citrea which produces antibiotic LL-E19085

This disclosure describes novel antibacterial agents designated LL-E10985.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.gamma. and LL-E19085.zeta., having the structure: ##STR1## their production by aerobic fermentation of a new subspecies of Micromonospora citrea NRRL 18351 and mutants thereof, and the isolation and purification thereof.

Antibiotic LL-E19085

This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.

Method for controlling chronic respiratory disease, fowl cholera and

Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.

Antibiotic LL-D42067.beta.

A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..

Process for producing antibiotic LL-D42067.alpha.

The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.

Culture and process for producing antibiotic LL-D42067alpha

This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.

Antibiotic LL-E19020 .alpha. and .beta.

This disclosure describes a new antibacterial agent designated LL-C23201.delta., produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces olivaceo-griseus, sp. nov. and mutants thereof. This new antibacterial agent is active against a variety of microorganisms and thus is useful in inhibiting the growth of such bacteria wherever they may be found.

Antibiotic LL-C23201.delta.

This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.

Biologically pure culture of Streptomyces majorciensis Labeda

Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.

Antibiotic LL-D42067.alpha.

This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.

Antibacterial antibiotics LL-CO8078.alpha..sub.1, .alpha..sub.2,

This invention relates to a novel process for the production of antibiotic X-14868A using the novel microorganism Antinomadura yumaense sp. nov.

Growing community of inventors

Spring Valley, NY, United States of America

Joseph J Goodman