Alcon Laboratories, Inc.

Oculus Contact Lens Company

Joseph J Falcetta

Joonsup Park

Wilhelm F Kunzler

Christina G Smith

Novel quaternary ammonium siloxane compounds and methods for their use are disclosed.

Quaternary ammonium siloxane compounds and methods for their use

Two compounds, which are derivatives of 2(2-hydroxyphenyl) 2H-benzotriazole, are copolymerized with hydrogel forming monomers to form ultraviolet absorbing hydrogels. These hydrogels have many potential applications. For instance, they can be used to make contact lenses and intraocular lenses which are particularly useful for aphakics.

Ultraviolet absorbing hydrogels

A copolymer for preparation of optical lenses obtained from siloxane monomers having aromatic ring and vinyl functionality.

Siloxane copolymers for ophthalmic applications

Copolymer compositions are prepared from a novel class of siloxane monomers in combination with hydroxyperfluoroalkylstyrenes, preferably p-(2-hydroxy hexafluoroisopropyl)sytrene [HFIS] monomer for ophthalmic applications.

p-(2-Hydroxy hexafluoroisopropyl) styrene [HFIS] monomer for ophthalmic

A material adapted to be used as a contact lens is made from a solid copolymer. The copolymer is made from an alkyl acrylate ester, an organosiloxane ester and a proteinaceous inhibiting wetting mixture of N-(1,1-dimethyl-3-oxobutyl)acrylamide and one or more acids selected from the group consisting of acrylic and methacrylic acid.

Material used for optical devices

Hydrogel compositions characterized by a copolymer composition which includes a hydroxyfluoroalkylstyrene as a comonomer. The preferred comonomer compound is p-(2-hydroxyhexafluoroisopropyl)-styrene [HFIS].

Hydrogel compositions using p-(2-hydroxyhexafluoroisopropyl) styrene as

Hydrogel polymeric material, suitable for preparing optical devices such as contact lenses. The material is of improved oxygen permeability and mechanical properties in comparison with conventional hydrogels. It comprises, in addition to the hydrogel material, from about 5% to about 60% by weight of a siloxane comonomer containing both an aromatic ring and vinyl functionality. Its cooperation and combination of performance characteristics with traditional hydrogel forming monomers provides a very useful polymeric material for making lenses of the soft hydrogel type.

Hydrogels containing siloxane comonomers

Novel colorless siloxane monomers containing both an aromatic ring and vinyl functionality are employed as a monomer for preparing copolymers that are ophthalmically useful. The monomer has good oxygen permeability, allows preparation of copolymers that have good machineability, and is easily wettable. Moreover, because of its compatability with other copolymers it can be useful to make a wide variety of types of lenses including hard and soft, and ocular implants as well.

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Arlington, TX, United States of America

Joseph J Falcetta