Advanced Medical Optics, Inc.

Novartis Ag

Alcon, Inc.

Allergan, Inc.

Allergan Sales, Inc.

Alcon Manufacturing, Ltd.

Joseph I Weinschenk, Iii

Douglas Schlueter

Mutlu Karakelle

Xiugao Liao

David Jinkerson

Chance Lehman

Massoud Ghazizadeh

Diana M Cordova

Glenn R Sussman

Jim Deacon

F Richard Christ

Harish C Makker

Charles X Liao

Frank Chang

Troy Vernon Holland

Walter R Laredo

Xiaoxiao Zhang

Stephen W Laguette

Charles Freeman

Uwe Haken

Albert R LeBoeuf

Ali E Akinay

Douglas C Schlueter

W Dennis Dean

The present invention is directed to adjustable chromophore compounds and materials (e.g., ophthalmic lens materials) incorporating those compounds. The adjustable chromophore compounds include a chemical moiety that structurally changes upon exposure to predetermined electromagnetic radiation (e.g., two photon radiation) as well as lens materials, particularly intraocular lens materials that incorporate those compounds.

Adjustable chromophore compounds and materials incorporating such compounds

Described herein is a method for producing UV-absorbing silicone hydrogel contact lenses, which is free or substantially free of internal stress and also is capable of blocking ultra-violet ('UV') radiation and optionally (but preferably) violet radiation with wavelengths from 381 nm to 440 nm, according to a photocuring technology, preferably according to the Lightstream Technology&#x2122;. This invention also provides UV-absorbing contact lenses made according to a method of the invention.

Method for making UV-absorbing ophthalmic lenses

High refractive index copolymers with reduced tack are disclosed. The copolymers, which are particularly suitable for use as ophthalmic device materials, comprise a benzhydryl methacrylate or benzhydryl methacrylate derivative monomer.

High refractive index ophthalmic device materials with reduced tack

Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Low-tack ophthalmic and otorhinolaryngological device materials

A two optic accommodative lens system wherein at least one of the optics is deformable. When compressed by the capsular bag, the two optics press against each other, deforming at least one of the optics. As a result, the interface where the two optics meet changes shape, thereby altering the refractive power of the lens system.

Accommodative intraocular lens system

UV absorbing compounds that are particularly useful in ophthalmic devices are disclosed.

UV-absorbers for ophthalmic lens materials

Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.

Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light

Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.

Intraocular lenses with unique blue-violet cutoff and blue light transmission characteristics

Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Ophthalmic lenses, such as intraocular lenses, include crosslinked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of 2-phenylpropyl acrylate or methacrylate and mixtures thereof, and a second constituent derived from a second component in an amount effective as a crosslinker in the crosslinked polymeric material. The crosslinked polymeric material has branched chain alkyl groups, in an amount effective to reduce the tackiness of the crosslinked polymeric material relative to a substantially identical crosslinked polymeric material without branched chain alkyl groups.

Intraocular lenses made from polymeric compositions and monomers useful in said compositions

Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

Intraocular lenses made from polymeric compositions

An intraocular lens for use in a mammalian eye includes an optic adapted to focus light toward a retina of the mammalian eye and, in cooperation with the mammalian eye, to provide accommodation, the optic including a first portion adapted to move in response to the action of the mammalian eye; and a second portion surrounded by the first portion, and having a higher index of refraction than the first portion and/or being less deformable than the first portion in response to forces exerted by the mammalian eye.

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Fort Worth, TX, United States of America

Joseph I Weinschenk, Iii