Immune Modulation, Inc.

Paraquest, Inc.

Joseph I Okogun

Emmanuel A Ojo-Amaize

Howard B Cottam

Emeka J Nchekwube

Vellalore N Kakkanaiah

Novel enhanced usage of hypoestoxides derivatives and agonists theeof as active agents against nucleated infectious entities including known parasites and the like microbiological insultors of living tissue, systems and organisms, known modes of administration and related compounds are used alone or in combination with the instant teachings.

Hypoestoxides, derivatives and agonists thereof for use of antiparasitic agents

A method for inhibiting the growth of lentiviruses and Herpetoviridae viruses, including HIV-1 and HSV-1, -2, respectively, in subjects, comprising administering to a subject in need of antiviral therapy a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR1## where: R is

Hypoestoxides, derivatives and agonists thereof for use as antiviral

A method for inhibiting the growth of cancer cells ous tumors. The method comprises administering to a subject in need of anticancer or antitumor therapy a pharmaceutical composition comprising a therapeutically effective amount of a compound of the formula ##STR1## where: R is

Hypoestoxides, derivatives and agonists thereof for use as anticancer

Methods and compounds for inducing immunosuppression in animals which need immunosuppressive treatment involving administration to animals of a therapeutically effective amount of a compound of the following formula ##STR1## where R is H, PO.sub.3.sup.=, alkyl of 1 to 12 carbon atoms substituted or unsubstituted, straight chain or branched, 0 to 6 double bonds, (CH.sub.2).sub.n morpholine where n=1-4, morpholinomethylphenyl, orthoaminophenyl, orthohydroxyphenyl, (CH.sub.2).sub.n COOR.sub.2 where n=1-4

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New Rochelle, NY, United States of America

Joseph I Okogun