Eli Lilly and Company

Joseph Henry Kennedy

Henry U Bryant

Jeffrey A Dodge

Alan David Palkowitz

Brian Stephen Muehl

Timothy Alan Shepherd

Kenneth Jeff Thrasher

Louis Nickolaus Jungheim

Kennan Joseph Fahey

Charles Willis Lugar, Iii

Roger L Robey

James Densmore Copp

Mark Louis Heiman

Charles A Alt

Kenneth Lee Hauser

Jeffrey Daniel Cohen

Andrew Michael Ratz

Gary A Rhodes

William Harlan Gritton

William George Trankle

David E Seyler

Scott Alan Jones

This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

Growth hormone secretagogues

C-8, 20-cyclo-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2''-O-demethylmacrocin and 2'-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.

Macrolide derivatives

Growing community of inventors

Noblesville, IN, United States of America

Joseph Henry Kennedy