Ethicon, Gmbh

Depuy Mitek, Inc.

Mentor Worldwide LLC

Ethicon Endo-surgery, Inc.

Advanced Technologies and Regenerative Medicine, LLC

Other

Cardinal Health Switzerland 515 Gmbh

Cordis Corporation

Janssen Biotech, Inc.

Gyroscope Therapeutics Limited

Orbit Biomedical Limited

Cilag International Gmbh

Joseph Henry Contiliano

David W Overaker

Jo Hays

Frederick E Shelton, IV

Charles J Scheib

Taylor W Aronhalt

Chunlin Yang

Jeffrey L Aldridge

Katherine J Schmid

Cortney E Henderson

Yufu Li

Mark B Roller

Qiang Zhang

Jenny J Yuan

Kevin L Cooper

Joseph H Sklar

Zhigang Li

Jeffrey S Swayze

Thomas Edward Meyer

Daniel J Abbott

Robert Burgermeister

Michael F Keane

Isaac John Khan

Vipul Bhupendra Dave

Marc Feinberg

Venkataramanan Mandakolathur Vasudevan

Kevor Shane TenHuisen

Mark C Tsai

Allen C Ho

Eugene L Timperman

Leo B Kriksunov

Michael S Cropper

Robert J Tannhauser

Duan Li Ou

Murty Narayan Vyakarnam

Joseph J Hammer

J Jenny Yuan

Chester O Baxter, Iii

Nathan Stewart Cauldwell

Tamara S Widenhouse

Donna L Korvick

Herbert Eugene Schwartz

Christopher J Schall

Mark D Timmer

Krasimira Hristov

Pallassana V Narayanan

Vikram August Garadi

Kelly R Brown

Ramesh Marrey

John Haroutunian

Krasmira Hristov

Iii Chester O Baxter

Iv Frederick E Shelton

A method of making an implantable prosthesis includes applying a gelling enhancer layer over an inner surface of a wall of a silicone shell having anterior and posterior walls surrounding an interior volume. The method includes filling the interior volume of the shell with a silicone gel and curing the silicone gel. The cured silicone gel that is located within a zone that is in the vicinity of the gelling enhancer layer has a higher level of cohesiveness than the cured silicone gel that is located outside the zone. The zone of the silicone gel having the higher level of cohesiveness has a thickness of 2-10 mm. The silicone gel located outside the zone has a first concentration level of a gelling enhancer and the silicone gel located within the zone has a second concentration level of the gelling enhancer that is 5%-300% greater than the first concentration level.

Methods of making implants having gel zones with higher levels of cohesiveness for eschewing scalloping, dimpling, and wrinkling

An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.

Therapeutic agent delivery device with convergent lumen

An implantable prosthesis includes a silicone shell having an apex, a base, a radius located between the apex and the base, and a dome extending between the apex and the radius. The silicone shell has an outer surface and an inner surface that surrounds an interior volume of the silicone shell. A silicone gel material is disposed within the interior volume of the silicone shell. A gelling enhancer layer containing a gelling enhancer covers the inner surface of the silicone shell. After the silicone gel material has been thermally cured, the silicone gel material that is located within a zone that is in the vicinity of the gelling enhancer layer has a higher level of cohesiveness than the silicone gel material that is located outside the zone. The gelling enhancer contains crosslinker and/or platinum catalyst, such as a Karstedt catalyst.

Implants having gel zones with higher levels of cohesiveness for eschewing scalloping, dimpling, and wrinkling

Implant shell having internal, global ribs

An implantable prosthesis includes a shell having an apex, a base, a radius located between the apex and the base, and a dome extending between the apex and the radius. The shell has an outer surface and an inner surface that surrounds an interior volume of the shell. At least one rib is integrally formed with the inner surface of the shell and projects inwardly from the inner surface of the shell into the interior volume of the shell. The shell has an interior volume that is adapted to receive a biocompatible filler material.

Systems, devices and methods of making mammary implants and tissue expanders having ribbed shells

Implant shell having internal, circumferential ribs

In various embodiments, an end effector comprising a first jaw, a second jaw, an implantable arrangement, first cavities, and second cavities is disclosed. At least one of the first and second jaws is movable to compress tissue between the first jaw and second jaws. The implantable arrangement comprises a first layer and a second layer. The first layer and the second layer comprise a polymeric composition. The first cavities are defined in the first layer and interconnectedly form a permeable first layer. The first cavities releasably retain a first therapeutic agent configured to induce a first biological response in the tissue. The second cavities are defined in the second layer and interconnectedly form a permeable second layer. The second cavities releasably retain a second therapeutic agent configured to induce a second biological response in the tissue. The first therapeutic agent and the second therapeutic agent are different.

End effector including an implantable arrangement

The present invention provides a fixation device that includes an elongate shank defining a longitudinal axis and having at least one engaging member for applying the fixation device within tissue and securing the fixation device in the tissue once implanted formed thereon, and a drive head having a proximal end, a distal end and a radial cross-sectional geometry, where the drive head is mated to the elongate shank, and includes at least one anti-rotational member integral therewith, Fixation device kits utilizing the fixation device, and methods of fixation in tissue are also provided.

Medical fixation devices with improved torsional drive head

A fastening system for fastening tissue that comprises a cartridge and an implant is disclosed. The cartridge comprises a cartridge body comprising removable fasteners. The implant comprises a first portion comprising a first absorbable polymer comprising a first compactness of first fibers and a first medicament releasably stored in the first compactness of the first fibers of the first portion. The implant further comprises a second portion comprising a second absorbable polymer comprising a second compactness of second fibers, wherein the second compactness is different than the first compactness. The second absorbable polymer is different than the first absorbable polymer. The implant further comprises a second medicament releasably stored in the second compactness of the second fibers of the second portion. The second medicament is different than the first medicament. The release of the second medicament and the release of the first medicament co-operatively produce a healing result.

Stapling system comprising implantable layers

A tissue thickness compensator comprising at least one woven lattice can be positioned in the end effector of a surgical instrument. A fastener cartridge that is positioned in the end effector can comprise at least one cavity configured to receive a fastener. The fastener can be moveable between an initial position, wherein the fastener is at least partially position in a cavity, and a fired position, wherein the fastener is configured to compress a woven lattice of the tissue thickness compensator. The woven lattice can comprise a resilient material such that compression of the woven lattice generates a restoring force. The woven lattice can also comprise an axis that can laterally traverse the fastener cartridge, diagonally traverse the fastener cartridge, or intersect a deck surface of the fastener cartridge. The woven lattice can comprise a hydrophilic substance, which can expand when the woven lattice is severed by a cutting element.

Tissue thickness compensator comprising resilient members

Methods of reducing device drag on implantable articles are disclosed herein. The methods include coating the contact surfaces of implantable articles with bioabsorbable lubricating coatings.

Bioabsorbable coatings of surgical devices

An end effector is disclosed. The end effector comprises a first jaw, a second jaw, wherein at least one of the first jaw and the second jaw is movable to compress tissue between the first jaw and the second jaw, and a cartridge body configured to receive a cutting member. The end effector further comprises a layer arrangement including a tissue contact surface and a plurality of therapeutic agents releasably contained within the layer arrangement, wherein each therapeutic agent is configured to either initially treat the tissue or sustainably treat the tissue in contact with the tissue contact surface, wherein one of the plurality of therapeutic agents is configured to be released by the cutting member, and wherein another of the plurality of therapeutic agents is configured to be released by an absorption process.

Tissue thickness compensators comprising therapeutic agents

Growing community of inventors

Stewartsville, NJ, United States of America

Joseph Henry Contiliano